{"id":23053,"date":"2004-05-10T13:16:09","date_gmt":"2004-05-10T13:16:09","guid":{"rendered":"https:\/\/corporate.webfactory.ferring.tech\/?p=23053"},"modified":"2021-05-10T19:31:41","modified_gmt":"2021-05-10T18:31:41","slug":"study-reveals-that-women-undergoing-a-cycle-of-ivf-treatment-with-menopur-may-have-a-significantly-improved-chance-of-becoming-pregnant","status":"publish","type":"post","link":"https:\/\/www.ferring.com\/study-reveals-that-women-undergoing-a-cycle-of-ivf-treatment-with-menopur-may-have-a-significantly-improved-chance-of-becoming-pregnant\/","title":{"rendered":"Study reveals that women undergoing a cycle of IVF treatment with MENOPUR may have a significantly improved chance of becoming pregnant"},"content":{"rendered":"[spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<h2 style=\"color: #0088ce\">Study reveals that women undergoing a cycle of IVF treatment with MENOPUR may have a significantly improved chance of becoming pregnant<\/h2>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<h3 style=\"color: #0088ce\">Lausanne, Switzerland \u2013 10 May, 2004 \u2013<\/h3>\n<p class=\"p1\">The publication was based on a sub-analysis of the landmark trial EISG (European-Israeli Study Group) which was designed to demonstrate non-inferiority of MENOPUR (HP-hMG) when compared with GONAL F (rFSH, Serono Group) in more than 700 IVF and ICSI patients.<\/p>\n<p>The sub-analysis showed impressive results: the ongoing pregnancy rate in the 233 women who underwent IVF was significantly higher in the MENOPUR group (31%) compared with the GONAL F group (20%), (p=0.037).<sup><span class=\"s1\"><a href=\"#note1\">1<\/a><\/span><\/sup><\/p>\n<p>The study analysis also showed that although less oocytes were retrieved in the MENOPUR group vs. GONAL F, MENOPUR appeared to have a clear beneficial effect on the pregnancy rates in women undergoing IVF.<\/p>\n<p>IVF procedures make up more than 60 percent of all ART (assisted reproduction treatment) procedures.<\/p>\n<p>To confirm these new results, Ferring is launching a state-of-the-art prospective, multi-national, comparative study powered to demonstrate superiority of MENOPUR vs GONAL F in IVF patients on ongoing pregnancy rate. The study called MERiT will be the largest, international prospective superiority trial comparing MENOPUR vs. GONAL F in IVF.<\/p>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<p>Included in the state of the art study design and innovative approaches:<\/p>\n<ul>\n<li>Centralized embryo assessments<\/li>\n<li>Intrafollicular endocrine environment<\/li>\n<li>Cryosurvival and frozen embryo cycles<\/li>\n<\/ul>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<p>Researchers are confident that the sub-results of EISG will be confirmed with MERiT as MENOPUR provides both FSH activity and LH activity (both of which are important contributors to achieving pregnancy). Several studies conclude that LH activity from either LH or hCG has several positive effects: it stimulates the development of high quality large follicles and it diminishes the number of small follicles which theoretically could reduce the risk of Ovarian Hyperstimulation Syndrome (OHSS).<sup><span class=\"s2\"><a href=\"#note2\">2<\/a><\/span><\/sup><\/p>\n<p>Interestingly new data also suggests that hCG\/LH activity may have a beneficial effect on the blood flow in the endometrium consequently improving the chances of successful egg implantation.<sup><span class=\"s3\"><a href=\"#note3\">3<\/a><\/span><\/sup><\/p>\n<p>According to the sub-analysis, adequate hCG levels during treatment with MENOPUR group appear to have a favourable impact on ongoing pregnancy rates in IVF and ICSI patients, but more markedly in IVF.<\/p>\n<p>The sub-analysis authors suggest that the beneficial effect of the LH activity in MENOPUR seen in IVF patients could also be mediated by cumulus oophorus cells which are present during the IVF and not during the ICSI procedure.<\/p>\n<p>&#8220;It is becoming increasingly evident that MENOPUR may have real advantages over rFSH (GONAL F) in IVF treatment for infertility&#8217;, said Dr. Pascal Danglas, vice-president of Clinical and Product Development at Ferring. &#8216;Studies like this are important because they provide evidence to identify the gonadotropin most likely to work best in certain populations. We are confident that our new study MERiT will echo these results.&#8221;<\/p>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<h3 style=\"color: #0088ce\">EISG Study Details<\/h3>\n<p>The EISG1 (European-Israeli Study Group) was an open-label, randomised, multi-center, multinational study to demonstrate non-inferiority of MENOPUR compared to GONAL F on going pregnancy rates.<\/p>\n<ul>\n<li>727 patients ( HP-hMG:373, rFSH:354)<\/li>\n<li>Long protocol, down-regulation with GnRH agonist (daily or depot)<\/li>\n<li>HP-hMG (MENOPUR) vs rFSH (GONAL F), subcutaneous route<\/li>\n<li>IVF\/ICSI and embryo transfer procedures according to center practice. Transfer of 1-3 developed embryos<\/li>\n<li>Luteal support according to center practice<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3 style=\"color: #0088ce\">About Ferring Pharmaceuticals<\/h3>\n<p class=\"p1\"><em>Ferring is a research driven, specialty biopharmaceutical group active in global markets.\u00a0 The company identifies, develops and markets innovative products in the areas of endocrinology, gastroenterology, gynecology, infertility and urology.<\/em><\/p>\n<p class=\"p1\"><em>In recent years Ferring has expanded beyond its traditional European base and now has operating subsidiaries in over 40 countries.<\/em><\/p>\n<p class=\"p1\">To learn more about Ferring or our products please visit us at<br \/>\n<a href=\"http:\/\/www.Ferring.com\/\">www.Ferring.com<\/a>.<\/p>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<h3 style=\"color: #0088ce\">For more information, please contact<\/h3>\n<p><strong>Sharmi Albrechtsen<br \/>\n<\/strong><em>Corporate Communication Manager, Ferring International Center<br \/>\n<\/em>+45 28 78 72 09<br \/>\n<span class=\"antispam\"><a href=\"mailto:sharmi.albrechtsen@ferring.com\">sharmi.albrechtsen@ferring.com<\/a><\/span><\/p>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<h3 style=\"color: #0088ce\">References<\/h3>\n<ol>\n<li id=\"note1\">The European and Israeli Study Group on Highly Purified menotropin versus Recombinant Follicle-Stimulating Hormone. Fertility and Sterility. 2004 May, 81(5)1401.<\/li>\n<li id=\"note2\">Filicori M et al. Human Reprod Update 2002 Nov-Dec; 8(6): 543-57.<\/li>\n<li id=\"note3\">Licht P. et al. Semin Reprod Med. 2001; 19(1): 37-47.<\/li>\n<\/ol>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_row element_name=&#8221;Row&#8221; wrap_type=&#8221;content-width&#8221; parallax_image_height=&#8221;content-height&#8221; parallax_image_movement=&#8221;fixed&#8221; parallax_image_speed=&#8221;0.5&#8243; bg_video_loop=&#8221;yes&#8221; parallax_video_height=&#8221;window-height&#8221; parallax_video_overlay=&#8221;none&#8221; row_overlay_opacity=&#8221;0&#8243; row_col_pos=&#8221;default&#8221; minimize_row=&#8221;no&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_button button_text=&#8221;READ MORE PRESS RELEASES&#8221; button_size=&#8221;standard&#8221; button_colour=&#8221;accent&#8221; button_type=&#8221;standard&#8221; rounded=&#8221;no&#8221; button_dropshadow=&#8221;no&#8221; button_link=&#8221;\/media\/press-releases\/&#8221; button_target=&#8221;_self&#8221; align=&#8221;center&#8221; animation=&#8221;none&#8221; animation_delay=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [\/spb_row]\n","protected":false},"excerpt":{"rendered":"<p>[spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] Study reveals that women undergoing a cycle of IVF treatment with MENOPUR may have a significantly improved chance of becoming pregnant [\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] Lausanne, Switzerland \u2013 10 May, 2004 \u2013 The publication was based on a sub-analysis of the landmark [&hellip;]<\/p>\n","protected":false},"author":2410,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[257],"tags":[],"class_list":["post-23053","post","type-post","status-publish","format-standard","hentry","category-press-release-2004"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.3 (Yoast SEO v23.3) - 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