{"id":22601,"date":"2018-06-27T10:20:41","date_gmt":"2018-06-27T10:20:41","guid":{"rendered":"https:\/\/corporate.webfactory.ferring.tech\/?p=22601"},"modified":"2021-05-10T11:43:28","modified_gmt":"2021-05-10T10:43:28","slug":"ferrings-heat-stable-carbetocin-could-save-thousands-of-womens-lives-by-preventing-excessive-bleeding-after-childbirth","status":"publish","type":"post","link":"https:\/\/www.ferring.com\/ferrings-heat-stable-carbetocin-could-save-thousands-of-womens-lives-by-preventing-excessive-bleeding-after-childbirth\/","title":{"rendered":"Ferring\u2019s heat-stable carbetocin could save thousands of women\u2019s lives by preventing excessive bleeding after childbirth"},"content":{"rendered":"[spb_boxed_content type=”coloured” box_link_target=”_self” padding_vertical=”0″ padding_horizontal=”0″ width=”1\/1″ el_position=”first last”]\n<h2 style=\"color: #0088ce;\">Ferring\u2019s heat-stable carbetocin could save thousands of women\u2019s lives by preventing excessive bleeding after childbirth<\/h2>\n[\/spb_boxed_content] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [spb_boxed_content type=”coloured” box_link_target=”_self” padding_vertical=”0″ padding_horizontal=”0″ width=”1\/1″ el_position=”first last”]\n<ul>\n<li>New data show heat-stable carbetocin is as effective as oxytocin, the current standard of care, in preventing excessive bleeding (postpartum haemorrhage (PPH)) following vaginal birth<a href=\"#note1\"><sup>1<\/sup><\/a><\/li>\n<\/ul>\n<ul>\n<li>Results from the largest study conducted in prevention of PPH with nearly 30,000 women, conducted by the World Health Organization, were published today in the New England Journal of Medicine<a href=\"#note1\"><sup>1<\/sup><\/a><\/li>\n<\/ul>\n<ul>\n<li>Publication concludes that the study should inform care in countries where cold-chain transport and storage of medicines is difficult to achieve and is a barrier to effective PPH prevention *<a href=\"#note1\"><sup>1<\/sup><\/a><\/li>\n<\/ul>\n[\/spb_boxed_content] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [spb_boxed_content type=”coloured” box_link_target=”_self” padding_vertical=”0″ padding_horizontal=”0″ width=”1\/1″ el_position=”first last”]\n<h3 style=\"color: #0088ce;\">Saint-Prex, Switzerland \u2013 27 June, 2018 \u2013<\/h3>\n<p class=\"p1\">Ferring Pharmaceuticals today announced new data demonstrating that its heat-stable formulation of carbetocin is as effective as the current standard of care, oxytocin, for the prevention of excessive bleeding, also known as postpartum haemorrhage (PPH), after vaginal birth.<sup><span class=\"s1\"><a href=\"#note1\">1<\/a><\/span><\/sup><\/p>\n[\/spb_boxed_content] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [spb_boxed_content type=”coloured” box_link_target=”_self” padding_vertical=”0″ padding_horizontal=”0″ width=”1\/1″ el_position=”first last”]\n<p>Results from the CHAMPION clinical trial, conducted by the World Health Organization (WHO) as part of a collaboration with Ferring and MSD for Mothers**, were published in the New England Journal of Medicine (NEJM).<sup><span class=\"s1\"><a href=\"#note1\">1<\/a><\/span><\/sup>\u00a0This is the largest study conducted in the prevention of PPH with nearly 30,000 women in ten countries.<sup><span class=\"s1\"><a href=\"#note1\">1<\/a><\/span><\/sup><\/p>\n<p>Every year, 14 million women are affected by PPH.<sup><span class=\"s1\"><a href=\"#note2\">2<\/a><\/span><\/sup> Although most deaths are preventable,<sup><span class=\"s1\"><a href=\"#note3\">3<\/a><\/span><\/sup>\u00a0PPH is the leading direct cause of maternal death worldwide,<sup><span class=\"s1\"><a href=\"#note4\">4<\/a><\/span><\/sup>\u00a0causing approximately 70,000 deaths per year.<sup><span class=\"s1\"><a href=\"#note4\">4<\/a><\/span><\/sup><\/p>\n<p>\u201cThis is an important step forwards in PPH prevention and these results pave the way for heat- stable carbetocin to potentially save the lives of thousands of women, especially in areas where cold-chain transport and storage is not feasible,\u201d said Professor Klaus Dugi, Chief Medical Officer, Ferring Pharmaceuticals. \u201cWe will now work with the WHO and MSD for Mothers to make heat- stable carbetocin available in countries where it is needed most, protecting women and families around the world.\u201d<\/p>\n<p>Researched and developed by Ferring as a solution to address unmet needs in women\u2019s health, heat-stable carbetocin remains effective at high temperatures,<sup><span class=\"s1\"><a href=\"#note5\">5<\/a><\/span><\/sup> addressing a significant limitation of oxytocin which must be stored and transported at 2 \u2013 8\u00b0C.<sup><span class=\"s1\"><a href=\"#note6\">6<\/a>,<a href=\"#note7\">7<\/a><\/span><\/sup>\u00a0Studies in low- and lower-middle income countries have revealed degradation and loss of efficacy in oxytocin ampoules, which could be due to inadequate storage and distribution conditions.<sup><a href=\"#note7\">7<\/a>,<a href=\"#note8\">8<\/a><\/sup>\u00a0Data show that heat-stable carbetocin maintains effectiveness for at least three years at 30\u00b0C and six months at 40\u00b0C.<sup><span class=\"s1\"><a href=\"#note5\">5<\/a><\/span><\/sup>\u00a0Heat-stable carbetocin has the potential to save thousands of women\u2019s lives in low- and lower-middle income countries, where 99% of PPH-related deaths occur2 and where the refrigeration of medicines can be difficult to achieve and maintain.<sup><span class=\"s1\"><a href=\"#note6\">6<\/a><\/span><\/sup><\/p>\n<p>The CHAMPION trial was conducted by the WHO Department of Reproductive Health and Research including the UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), using Ferring\u2019s heat-stable carbetocin, and funded by MSD for Mothers.<sup><span class=\"s1\"><a href=\"#note1\">1<\/a><\/span><\/sup><sup>,<span class=\"s1\"><a href=\"#note6\">6<\/a><\/span><\/sup>\u00a0Ferring will now seek registrations and manufacture heat-stable carbetocin. The parties will work together with the aim of making heat- stable carbetocin available at an affordable and sustainable price in the public sector of low- and lower-middle income countries that have a high burden of maternal mortality.<\/p>\n<p>* The availability of heat-stable carbetocin is subject to regulatory review and approval in relevant countries.<br \/>\n** Known as Merck & Co., Inc., Kenilworth, N.J., U.S.A.<\/p>\n[\/spb_boxed_content] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [spb_boxed_content type=”coloured” box_link_target=”_self” padding_vertical=”0″ padding_horizontal=”0″ width=”1\/1″ el_position=”first last”]\n<h3 style=\"color: #0088ce;\">About the CHAMPION trial<\/h3>\n<p>CHAMPION, (Carbetocin Haemorhage Prevention), the largest clinical trial in the prevention of PPH, was a double-blind, randomised, non-inferiority trial designed to compare the effectiveness and safety of investigational heat-stable carbetocin to oxytocin in the prevention of PPH after vaginal birth. The trial, conducted by the WHO Department of Reproductive Health and Research including the UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in HRP, enrolled nearly 30,000 women in ten countries including Argentina, Egypt, India, Kenya, Nigeria, Singapore, South Africa, Thailand, Uganda and the UK. Heat-stable carbetocin was researched and developed by Ferring Pharmaceuticals and the CHAMPION trial was funded by MSD for Mothers.<\/p>\n<p>Results demonstrated that heat-stable carbetocin is clinically non-inferior to oxytocin for the primary outcome of \u2265500 ml blood loss or additional uterotonic use. The frequency of blood loss of \u2265500 ml or additional uterotonic use was 14.5% in the carbetocin group and 14.4% in the oxytocin group (Relative Risk (RR): 1.01 95% confidence interval (CI) 0.95 to 1.06), consistent with non-inferiority.<\/p>\n<p>Non-inferiority was not demonstrated for the second primary outcome of blood loss of \u2265 1,000 ml (1.51% carbetocin group vs 1.45% in the oxytocin group, RR: 1.04, CI: 0.87 to 1.25); however, the trial was underpowered for this outcome. There were no significant differences between groups in other measures of bleeding or in adverse effects.<\/p>\n<h3 style=\"color: #0088ce;\">About Ferring Pharmaceuticals<\/h3>\n<p>Ferring Pharmaceuticals is a research-driven, speciality biopharmaceutical group committed to helping people around the world build families and live better lives. Headquartered in Saint-Prex, Switzerland, Ferring is a leader in reproductive medicine and women\u2019s health, and in speciality areas within gastroenterology and urology. Ferring has been developing treatments for mothers and babies for over 50 years and has a portfolio covering treatments from conception to birth. Founded in 1950, privately-owned Ferring now employs approximately 6,500 people worldwide, has its own operating subsidiaries in nearly 60 countries and markets its products in 110 countries.<\/p>\n<p>Learn more at\u00a0<a href=\"https:\/\/www.ferring.com\/\">www.ferring.com<\/a>, or connect with us on\u00a0<a href=\"https:\/\/twitter.com\/ferring\">Twitter<\/a>,\u00a0<a href=\"https:\/\/www.facebook.com\/ferringpharmaceuticals\/\">Facebook<\/a>,\u00a0<a href=\"https:\/\/www.instagram.com\/ferringpharmaceuticals\/\">Instagram<\/a>,\u00a0<a href=\"https:\/\/www.linkedin.com\/company\/ferring-pharmaceuticals\/\">LinkedIn<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.youtube.com\/channel\/UC6Ss0Uwv54xTGmM_EDEzQPA\">YouTube<\/a>.<\/p>\n[\/spb_boxed_content] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [spb_boxed_content type=”coloured” box_link_target=”_self” padding_vertical=”0″ padding_horizontal=”0″ width=”1\/1″ el_position=”first last”]\n<h3 style=\"color: #0088ce;\">For more information, please contact<\/h3>\n<p><strong>Bhavin Vaid<br \/>\n<\/strong><em>Head of Corporate Communications<br \/>\n<\/em>+41 58 301 09 52 (direct)<br \/>\n+41 79 191 06 32 (mobile)<br \/>\n<span class=\"antispam\"><a href=\"mailto:bhavin.vaid@ferring.com\">bhavin.vaid@ferring.com<\/a><\/span><\/p>\n<p><strong>Lindsey Rodger<br \/>\n<\/strong><em>Senior Manager, Corporate Communications<br \/>\n<\/em>+41 58 451 40 23 (direct)<br \/>\n+41 79 191 0486 (mobile)<br \/>\n<span class=\"antispam\"><a href=\"mailto:lindsey.rodger@ferring.com\">lindsey.rodger@ferring.com<\/a><\/span><\/p>\n<p><strong>Patrick Gorman<\/strong><br \/>\nDirector, Ferring Pharmaceuticals USA<br \/>\n+1 862 286 5035 (direct)<br \/>\n<span class=\"antispam\"><a href=\"mailto:patrick.gorman@ferring.com\">patrick.gorman@ferring.com<\/a><\/span><\/p>\n[\/spb_boxed_content] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [spb_boxed_content type=”coloured” box_link_target=”_self” padding_vertical=”0″ padding_horizontal=”0″ width=”1\/1″ el_position=”first last”]\n<h3 style=\"color: #0088ce;\">References<\/h3>\n<ol>\n<li id=\"note1\">Widmer M,\u00a0et al\u00a0. Heat stable carbetocin vs oxytocin to prevent hemorrhage after vaginal birth.\u00a0New England Journal of Medicine\u00a02018;in press.<\/li>\n<li id=\"note2\">World Health Organization. Priority diseases and reasons for inclusion. Postpartum haemorrhage. Available at:\u00a0<a href=\"http:\/\/www.who.int\/medicines\/areas\/priority_medicines\/Ch6_16PPH.pdf\">http:\/\/www.who.int\/medicines\/areas\/priority_medicines\/Ch6_16PPH.pdf<\/a>\u00a0Last accessed: May 2018.<\/li>\n<li id=\"note3\">World Health Organization. WHO recommendations for the prevention and treatment of postpartum haemorrhage. Published 2012. Available at:\u00a0<a href=\"https:\/\/www.who.int\/reproductivehealth\/publications\/maternal_perinatal_health\/9789241548502\/en\/\">https:\/\/www.who.int\/reproductivehealth\/publications\/maternal_perinatal_health\/9789241548502\/en\/<\/a>\u00a0Last accessed: May 2018.<\/li>\n<li id=\"note4\">Say L, et al . Global causes of maternal death: a WHO systematic analysis. The Lancet Global Health. 2014; 2(6):e323-33. Available at: <a href=\"https:\/\/doi.org\/10.1016\/S2214-109X(14)70227-X\">https:\/\/doi.org\/10.1016\/S2214-109X(14)70227-X<\/a><br \/>\nLast accessed: May 2018.<\/li>\n<li id=\"note5\">Malm M,\u00a0et al.\u00a0Development and stability of a heat-stable formulation of carbetocin for the prevention of postpartum haemorrhage for use in low and middle-income countries.\u00a0Journal of Peptide Science\u00a02018;e3082.<\/li>\n<li id=\"note6\">Widmer M,\u00a0et al.\u00a0Room temperature stable carbetocin for the prevention of postpartum haemorrhage during the third stage of labour in women delivering vaginally: study protocol for a randomized controlled trial.\u00a0Trials\u00a02016;17(1):143.<\/li>\n<li id=\"note7\">Torloni MR,\u00a0et al.\u00a0Quality of Oxytocin Available in Low and Middle-Income Countries: A Systematic Review of the Literature (Systematic Review on Quality of Oxytocin).\u00a0An International Journal of Obstetrics and Gynaecology\u00a02016;123(13):2076-2086.<\/li>\n<li id=\"note8\">Anyakora,\u00a0et al.\u00a0Quality medicines in maternal health: results of oxytocin, misoprostol, magnesium sulfate and calcium gluconate quality audits.\u00a0BMC Pregnancy and Childbirth\u00a02018;18:44.<\/li>\n<\/ol>\n[\/spb_boxed_content] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [spb_row element_name=”Row” wrap_type=”content-width” parallax_image_height=”content-height” parallax_image_movement=”fixed” parallax_image_speed=”0.5″ bg_video_loop=”yes” parallax_video_height=”window-height” parallax_video_overlay=”none” row_overlay_opacity=”0″ row_col_pos=”default” minimize_row=”no” width=”1\/1″ el_position=”first last”] [spb_button button_text=”READ MORE PRESS RELEASES” button_size=”standard” button_colour=”accent” button_type=”standard” rounded=”no” button_dropshadow=”no” button_link=”\/media\/press-releases\/” button_target=”_self” align=”center” animation=”none” animation_delay=”0″ width=”1\/1″ el_position=”first last”] [\/spb_row]\n","protected":false},"excerpt":{"rendered":"<p>[spb_boxed_content type=”coloured” box_link_target=”_self” padding_vertical=”0″ padding_horizontal=”0″ width=”1\/1″ el_position=”first last”] Ferring\u2019s heat-stable carbetocin could save thousands of women\u2019s lives by preventing excessive bleeding after childbirth [\/spb_boxed_content] [spb_blank_spacer height=”30px” width=”1\/1″ el_position=”first last”] [spb_boxed_content type=”coloured” box_link_target=”_self” padding_vertical=”0″ padding_horizontal=”0″ width=”1\/1″ el_position=”first last”] New data show heat-stable carbetocin is as effective as oxytocin, the current standard of care, in preventing excessive bleeding (postpartum haemorrhage (PPH)) following […]<\/p>\n","protected":false},"author":2410,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[243],"tags":[],"class_list":["post-22601","post","type-post","status-publish","format-standard","hentry","category-press-release-2018"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.3 (Yoast SEO v23.3) - 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