{"id":22411,"date":"2019-12-05T09:13:49","date_gmt":"2019-12-05T09:13:49","guid":{"rendered":"https:\/\/corporate.webfactory.ferring.tech\/?p=22411"},"modified":"2021-05-10T17:44:10","modified_gmt":"2021-05-10T16:44:10","slug":"fergene-announces-pivotal-phase-3-study-of-nadofaragene-firadenovec","status":"publish","type":"post","link":"https:\/\/www.ferring.com\/fergene-announces-pivotal-phase-3-study-of-nadofaragene-firadenovec\/","title":{"rendered":"FerGene announces pivotal Phase 3 study of nadofaragene firadenovec"},"content":{"rendered":"[spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<h2 style=\"color: #0088ce\">FerGene announces pivotal Phase 3 study of nadofaragene firadenovec met its primary endpoint with more than half of patients with high-grade non-muscle invasive bladder cancer (CIS \u00b1 Ta\/T1) achieving a complete response at three months<\/h2>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<ul>\n<li>The multi-center study met its primary endpoint with 53% of CIS \u00b1 Ta\/T1 patients achieving a complete response (CR) at three months, and 24% continuing to show a CR at 12 months<\/li>\n<\/ul>\n<ul>\n<li>Additional data show 73% high-grade recurrence free (HGRF) survival in patients with papillary disease at three months and 44% HGRF survival at 12 months<\/li>\n<\/ul>\n<ul>\n<li>Clinical results also support a favorable safety and tolerability profile for nadofaragene firadenovec<\/li>\n<\/ul>\n<ul>\n<li>Nadofaragene firadenovec is administered intravesically once every three months<\/li>\n<\/ul>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<h3 class=\"p1\" style=\"color: #0088ce\">Washington D.C, US \u2013 December 5, 2019<\/h3>\n<p class=\"p1\">FerGene, a new gene therapy company formed by Ferring Pharmaceuticals and Blackstone Life Sciences, announced today positive results from the pivotal Phase 3 clinical trial evaluating nadofaragene firadenovec (rAd-IFN\/Syn3), an investigational gene therapy, for the treatment of high-grade, Bacillus Calmette-Gu\u00e9rin (BCG) unresponsive non-muscle invasive bladder cancer (NMIBC). FKD Therapies Oy (FKD) has led the development and regulatory filing of nadofaragene firadenovec, which has been studied in 33 centers across the U.S. in collaboration with the Society of Urologic Oncology Clinical Trials Consortium (SUO-CTC). The results were presented during the bladder cancer session at the Society of Urologic Oncology 20th Annual Meeting in Washington D.C.<\/p>\n<p class=\"p1\">The Phase 3 study of 157 patients from the U.S. met its primary endpoint with 53% of CIS \u00b1 Ta\/T1 patients (carcinoma in situ; bladder cancer that is confined to the superficial layer, with or without concomitant high-grade Ta or T1 papillary disease) achieving a CR at three months, and 24% continuing to show a CR at 12 months. Moreover, the study also demonstrated broad efficacy in this difficult to treat patient population with a 73% HGRF survival in patients with papillary disease at three months and 44% HGRF survival at 12 months. In the study, nadofaragene firadenovec was instilled directly into the patients\u2019 bladder every three months. All responses at 12 months were confirmed by protocol-mandatory five-point biopsies.<\/p>\n<p class=\"p1\">Bladder cancer is one of the most frequently occurring cancers with an estimated 699,450 people living with bladder cancer and more than 80,000 new cases diagnosed each year in the U.S. alone. In high-grade NMIBC patients, BCG is the standard treatment, and, although effective, over 60% of these tumors eventually re-occur.<sup><a href=\"#note2\">2<\/a>,<a href=\"#note3\">3<\/a><\/sup><\/p>\n<p class=\"p1\"><em>\u201cCurrently, patients living with high-grade NMIBC who are unresponsive to BCG have few treatment options and often face bleak outcomes, including complete bladder removal, known as cystectomy,\u201d said Colin P. N. Dinney, MD, Professor and Chairman of the Department of Urology at The University of Texas M.D. Anderson Cancer Center. \u201cCystectomy is a complex and life-altering surgical procedure for patients, so these positive results from the Phase 3 trial of nadofaragene firadenovec are highly promising for patients. It would be gratifying to provide an alternative that addresses the critical unmet need for effective second-line therapy for patients facing radical cystectomy.\u201d<\/em><\/p>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<h3 style=\"color: #0088ce\">Efficacy Analysis<\/h3>\n<table border=\"0\" width=\"672\">\n<tbody>\n<tr>\n<td width=\"101\"><strong>Assessment Period<\/strong><\/td>\n<td width=\"235\"><strong>CIS \u00b1 Ta\/T1 Disease (n=103) CR (% [n])<\/strong><\/td>\n<td width=\"336\"><strong>High-Grade Ta\/T1 Papillary Disease (non CIS)<\/strong>&nbsp;<\/p>\n<p><strong>(n=48) HGRF Survival (% [n])<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"101\"><strong>Month 3<\/strong><\/td>\n<td width=\"235\">53.4% (55)<\/td>\n<td width=\"336\">72.9% (35)<\/td>\n<\/tr>\n<tr>\n<td width=\"101\"><strong>Month 6<\/strong><\/td>\n<td width=\"235\">40.8% (42)<\/td>\n<td width=\"336\">62.5% (30)<\/td>\n<\/tr>\n<tr>\n<td width=\"101\"><strong>Month 9<\/strong><\/td>\n<td width=\"235\">35.0% (36)<\/td>\n<td width=\"336\">58.3% (28)<\/td>\n<\/tr>\n<tr>\n<td width=\"101\"><strong>Month 12<\/strong><\/td>\n<td width=\"235\">24.3% (25)<\/td>\n<td width=\"336\">43.8% (21)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"p1\"><span class=\"s1\"><b><i>*151 patients<\/i><\/b><\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">In the Phase 3 trial, the most common adverse events (AEs) included fatigue, bladder spasm and discharge around the catheter, micturition urgency, hematuria, chills, fever, headache, painful urination, urinary tract infection, and diarrhea. No grade 4 or 5 treatment-related AEs were reported in the study. Study drug-related AEs were transient and local in nature, with a median duration of less than two days, with the exception of fatigue, which had a median duration of 11 days and urinary frequency which had a median duration of 41 days. There was a 1.9% percent rate of discontinuations due to study drug-related AEs.<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">\u201c<i>We are pleased with these Phase 3 data results, including the complete response rates and favorable safety profile seen with nadofaragene firadenovec,<\/i>\u201d said Nigel R. Parker,<\/span><span class=\"s2\"><sup><a href=\"#note4\">4<\/a><\/sup><\/span><span class=\"s1\">\u00a0PhD, of FKD Therapies Oy. \u201c<i>These data were part of our submission package to the FDA, and we look forward to continuing to work with the agency to potentially bring nadofaragene firadenovec to patients with BCG unresponsive disease.<\/i>\u201d<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">\u201c<i>As a practicing urologist and trial investigator, it\u2019s encouraging to see these types of efficacy and safety results in patients with high-grade NMIBC, an area that\u2019s been in need of new innovative treatment options for more than 20 years,<\/i>\u201d said Neal Shore, MD, FACS, Medical Director, Carolina Urologic Research Center. \u201c<i>These robust clinical results further demonstrate the potential of nadofaragene firadenovec as a valuable treatment option for NMIBC patients.<\/i>\u201d<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">The U.S. Food and Drug Administration (FDA) has validated FKD\u2019s Biologics License Application (BLA) and granted Priority Review for nadofaragene firadenovec, which previously received Fast Track and Breakthrough Therapy Designations.<\/span><\/p>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<h3 class=\"p1\" style=\"color: #0088ce\">About nadofaragene firadenovec<\/h3>\n<p class=\"p1\"><span class=\"s1\">Nadofaragene firadenovec (rAd-IFN\/Syn3) is an investigational gene therapy being developed as a treatment for patients with high-grade, BCG unresponsive, NMIBC. It is an adenovirus vector-based gene therapy containing the gene interferon alfa-2b, administered by catheter into the bladder every three months. The vector enters the cells of the bladder wall, where, it breaks down, releasing the active gene to do its work. The internal gene\/DNA machinery of the cells \u2018picks up\u2019 the gene and translates its DNA sequence, resulting in the cells secreting high quantities of interferon alfa-2b protein, a naturally occurring protein the body uses to fight cancer. This novel gene therapy approach thereby turns the patient&#8217;s own bladder wall cells into multiple interferon microfactories, enhancing the body&#8217;s natural defenses against the cancer.<\/span><\/p>\n<h3 class=\"p1\" style=\"color: #0088ce\">About Non-Muscle Invasive Bladder Cancer (NMIBC)<\/h3>\n<p class=\"p1\"><span class=\"s1\">NMIBC is an early form of bladder cancer which is present in the superficial layer of the bladder and has not invaded deeper into the bladder or spread to other parts of the body.<\/span><a href=\"#note5\"><span class=\"s2\"><sup>5<\/sup><\/span><\/a><span class=\"s1\"> It is estimated that there will be 80,000 new cases of bladder cancer in the U.S. in 2019; more than 70% of these cases present as NMIBC.<sup><a href=\"#note2\">2<\/a><\/sup><\/span><span class=\"s2\"><sup>,<a href=\"#note6\">6<\/a><\/sup><\/span><span class=\"s1\">\u00a0In patients with high-grade NMIBC, intravesical BCG is the recommended treatment; however, between 30% and 50% cases with high-grade disease will recur. The outcome for BCG unresponsive patients is poor, with total cystectomy (complete removal of the bladder) often being the next treatment option.<\/span><a href=\"#note8\"><span class=\"s2\"><sup>8<\/sup><\/span><\/a><\/p>\n<h3 class=\"p1\" style=\"color: #0088ce\">About FerGene<\/h3>\n<p class=\"p1\"><span class=\"s1\">FerGene, a new gene therapy company and Ferring subsidiary, has been created to potentially commercialize nadofaragene firadenovec in the U.S. and to advance the global clinical development. FerGene\u2019s goal is to bring this promising therapy to a patient population which has seen little improvement in their standard of care over the past twenty years. Blackstone Life Sciences will invest $400 million USD and Ferring will invest up to $170 million USD in FerGene. Ferring will also potentially launch and commercialize nadofaragene firadenovec outside of the U.S.<\/span><\/p>\n<h3 class=\"p1\" style=\"color: #0088ce\">About FKD Therapies Oy<\/h3>\n<p class=\"p1\"><span class=\"s1\">FKD Therapies Oy is a specialist gene therapy company based in Kuopio, Finland originally conceived by scientific and medical founders, Dr Nigel R Parker and Professor Seppo Yla-Herttuala,<\/span><a href=\"#note4\"><span class=\"s2\"><sup>4<\/sup><\/span><\/a><span class=\"s1\">\u00a0for the specific purpose of undertaking the development of adenovirus mediated interferon alfa-2b. FKD has led the overall development of nadofaragene firadenovec through manufacturing at FinVector Oy, late stage clinical trials and the current BLA filing. FinVector Oy and FKD Oy are part of the Trizell Group.<\/span><\/p>\n<h3 class=\"p1\" style=\"color: #0088ce\">About Ferring Pharmaceuticals<\/h3>\n<p class=\"p1\"><span class=\"s1\">Ferring Pharmaceuticals is a research-driven, specialty biopharmaceutical group committed to helping people around the world build families and live better lives. Headquartered in Saint-Prex, Switzerland, Ferring is a leader in reproductive medicine and women\u2019s health, and in specialty areas within gastroenterology and urology. Ferring has been developing treatments for mothers and babies for over 50 years and has a portfolio covering treatments from conception to birth. Founded in 1950, privately-owned Ferring now employs approximately 6,500 people worldwide, has its own operating subsidiaries in nearly 60 countries and markets its products in 110 countries.<\/span><\/p>\n<p class=\"p2\"><span class=\"s4\">Learn more at\u00a0<a href=\"https:\/\/www.ferring.com\/\"><span class=\"s5\">www.ferring.com<\/span><\/a>, or connect with us on <a href=\"https:\/\/twitter.com\/ferring\"><span class=\"s5\">Twitter<\/span><\/a>,\u00a0<a href=\"https:\/\/www.facebook.com\/ferringpharmaceuticals\/\"><span class=\"s5\">Facebook<\/span><\/a>,\u00a0<a href=\"https:\/\/www.instagram.com\/ferringpharmaceuticals\/\"><span class=\"s5\">Instagram<\/span><\/a>,\u00a0<a href=\"https:\/\/www.linkedin.com\/company\/163789\/admin\/\"><span class=\"s5\">LinkedIn<\/span><\/a>\u00a0and\u00a0<a href=\"https:\/\/www.youtube.com\/channel\/UC6Ss0Uwv54xTGmM_EDEzQPA\"><span class=\"s5\">YouTube<\/span><\/a>.<\/span><\/p>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<h3 class=\"p1\" style=\"color: #0088ce\">For more information, please contact<\/h3>\n<p><span class=\"s1\"><b>Terri Mueller<\/b><\/span><span class=\"s3\"><br \/>\n<\/span><em><span class=\"s1\">Head, Communications &amp; Advocacy<\/span><\/em><span class=\"s3\"><br \/>\n<\/span><span class=\"s1\">Ferring Pharmaceuticals<\/span><span class=\"s3\"><br \/>\n<a href=\"mailto:terri.mueller@ferring.com\"><span class=\"s6\">terri.mueller@ferring.com<\/span><\/a><\/span><\/p>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]\n<h3 class=\"p1\" style=\"color: #0088ce\">References<\/h3>\n<ol>\n<li id=\"note1\">National Cancer Institute. Cancer Stat Facts: Bladder Cancer. Available at:\u00a0<a href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fseer.cancer.gov%2Fstatfacts%2Fhtml%2Furinb.html&amp;esheet=52132164&amp;newsitemid=20191125005439&amp;lan=en-US&amp;anchor=https%3A%2F%2Fseer.cancer.gov%2Fstatfacts%2Fhtml%2Furinb.html&amp;index=7&amp;md5=669e7404d653256915b3ce94fff599db\"><span class=\"s5\">https:\/\/seer.cancer.gov\/statfacts\/html\/urinb.html<\/span><\/a>. Last accessed: December 2019.<\/li>\n<li id=\"note2\">Maruf, M\u00a0<i>et al<\/i>., Non invasive bladder cancer: a primer on immunotherapy.\u00a0<i>Cancer Biol Med.<\/i> 2016;13(2):194-205.<\/li>\n<li id=\"note3\">Derr\u00e9, L\u00a0<i>et al<\/i>., Intravesical Bacillus Calmette Guerin Combined with a Cancer Vaccine Increases Local T-Cell Responses in Non-muscle-Invasive Bladder Cancer Patients.\u00a0<a href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F27521445&amp;esheet=52132164&amp;newsitemid=20191125005439&amp;lan=en-US&amp;anchor=Clin+Cancer+Res&amp;index=8&amp;md5=8a9050f76cef3988baf9003341fd7077\"><span class=\"s5\"><i>Clin Cancer Res<\/i><\/span><\/a><i>.\u00a0<\/i>2017;23(3):717-725.<\/li>\n<li id=\"note4\">AIV Institute for Molecular Sciences, Kuopio, Finland.<\/li>\n<li id=\"note5\">Anastasiadis A, de Reijke TM. Best practice in the Treatment of Nonmuscle Invasive Bladder Cancer. <i>Ther Adv Urol<\/i>. 2012;4(1):13-32<\/li>\n<li id=\"note6\">Ghatalia, Pooja et al. \u201cApproved checkpoint inhibitors in bladder cancer: which drug should be used when?.\u201d <i>Therapeutic advances in medical oncology<\/i> vol. 10 1758835918788310. 30 Jul. 2018, doi:10.1177\/1758835918788310.<\/li>\n<li id=\"note7\">Cambier S et al. EORTC Nomograms and Risk Groups for Predicting Recurrence, Progression, and Disease-specific and Overall Survival in Non\u2013Muscle-invasive Stage Ta\u2013T1 Urothelial Bladder Cancer Patients Treated with 1\u20133 Years of Maintenance Bacillus Calmette-Gu\u00e9rin. European Urolology. 2016, Vol. 69(1): 60-69.<\/li>\n<li id=\"note8\">Cookson, M et al.,Use of intravesical valrubicin in clinical practice for treatment of nonmuscle-invasive bladder cancer, including carcinoma in situ of the bladder. Therapeutic Advances in Urology. 2014, Vol. 5(5):181-191.<\/li>\n<\/ol>\n[\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_button button_text=&#8221;READ MORE PRESS RELEASES&#8221; button_size=&#8221;standard&#8221; button_colour=&#8221;accent&#8221; button_type=&#8221;standard&#8221; rounded=&#8221;no&#8221; button_dropshadow=&#8221;no&#8221; button_link=&#8221;\/media\/press-releases\/&#8221; button_target=&#8221;_self&#8221; align=&#8221;center&#8221; animation=&#8221;none&#8221; animation_delay=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] FerGene announces pivotal Phase 3 study of nadofaragene firadenovec met its primary endpoint with more than half of patients with high-grade non-muscle invasive bladder cancer (CIS \u00b1 Ta\/T1) achieving a complete response at three months [\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] The multi-center study [&hellip;]<\/p>\n","protected":false},"author":2410,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[242],"tags":[],"class_list":["post-22411","post","type-post","status-publish","format-standard","hentry","category-press-release-2019"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.3 (Yoast SEO v23.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>FerGene announces pivotal Phase 3 study of nadofaragene firadenovec - Ferring Global<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ferring.com\/fergene-announces-pivotal-phase-3-study-of-nadofaragene-firadenovec\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FerGene announces pivotal Phase 3 study of nadofaragene firadenovec\" \/>\n<meta property=\"og:description\" content=\"[spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] FerGene announces pivotal Phase 3 study of nadofaragene firadenovec met its primary endpoint with more than half of patients with high-grade non-muscle invasive bladder cancer (CIS \u00b1 Ta\/T1) achieving a complete response at three months [\/spb_boxed_content] [spb_blank_spacer height=&#8221;30px&#8221; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] [spb_boxed_content type=&#8221;coloured&#8221; box_link_target=&#8221;_self&#8221; padding_vertical=&#8221;0&#8243; padding_horizontal=&#8221;0&#8243; width=&#8221;1\/1&#8243; el_position=&#8221;first last&#8221;] The multi-center study [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ferring.com\/fergene-announces-pivotal-phase-3-study-of-nadofaragene-firadenovec\/\" \/>\n<meta property=\"og:site_name\" content=\"Ferring Global\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ferringpharmaceuticals\/\" \/>\n<meta property=\"article:published_time\" content=\"2019-12-05T09:13:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-05-10T16:44:10+00:00\" \/>\n<meta name=\"author\" content=\"pulse\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ferring\" \/>\n<meta name=\"twitter:site\" content=\"@ferring\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"pulse\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.ferring.com\/fergene-announces-pivotal-phase-3-study-of-nadofaragene-firadenovec\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.ferring.com\/fergene-announces-pivotal-phase-3-study-of-nadofaragene-firadenovec\/\"},\"author\":{\"name\":\"pulse\",\"@id\":\"https:\/\/www.ferring.com\/#\/schema\/person\/d1f92e22aded72904a8e0a8cdc7bcd3d\"},\"headline\":\"FerGene announces pivotal Phase 3 study of nadofaragene firadenovec\",\"datePublished\":\"2019-12-05T09:13:49+00:00\",\"dateModified\":\"2021-05-10T16:44:10+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.ferring.com\/fergene-announces-pivotal-phase-3-study-of-nadofaragene-firadenovec\/\"},\"wordCount\":1788,\"publisher\":{\"@id\":\"https:\/\/www.ferring.com\/#organization\"},\"articleSection\":[\"PRESS RELEASE 2019\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.ferring.com\/fergene-announces-pivotal-phase-3-study-of-nadofaragene-firadenovec\/\",\"url\":\"https:\/\/www.ferring.com\/fergene-announces-pivotal-phase-3-study-of-nadofaragene-firadenovec\/\",\"name\":\"FerGene announces pivotal Phase 3 study of nadofaragene firadenovec - 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